NURSING ANM AND GNM

NURSING EXAM QUESTIONS

BIOCHEMISTRY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Why is the “lock and key” analogy often used to describe enzymefunction?
A
Each enzyme is the same as its substrate.
B
Each enzyme will fit with only one specific kind of substrate.
C
Each enzyme can only be used once in a reaction and cannot be usedagain.
D
Each enzyme has its own active site that will not fit with other activesites.
Explanation: 

Detailed explanation-1: -A Lock and Key analogy may be used to describe the fundamental action of a single substrate enzyme. In this case, the enzyme is the lock, and the substrate is the key. Only the correct size key, which is the substrate, enters the keyhole, which is the active site of the lock, which is the enzyme.

Detailed explanation-2: -Lock-and-key model is a model for enzyme-substrate interaction suggesting that the enzyme and the substrate possess specific complementary geometric shapes that fit exactly into one another. Enzymes are highly specific. They must bind to a specific substrate before they can catalyze a chemical reaction.

Detailed explanation-3: -Similar to the concept of lock and key, only the substrate of a specific shape can fit into the active site of an enzyme. The analogy is not that perfect since inserting the key into a lock is a physical process, compared to the binding of the substrates at the active site of an enzyme which is a chemical process.

Detailed explanation-4: -Lock and Key Model He proposed that this is due to the shape of the enzyme fitting the shape of the substrate, similar to how a lock only fits a specific key. Using this analogy, the enzyme represents the lock and the substrate represents the key.

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