NURSING EXAM QUESTIONS
MICROBIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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modifying the active site.
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to activate the enzyme.
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forming a holoenzyme.
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all of the above.
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Detailed explanation-1: -Coenzymes bind to the apoenzyme and assist in enzyme activity. A coenzyme is technically a type of cofactor.
Detailed explanation-2: -A cofactor that is firmly bound to the apoenzyme and cannot be removed without denaturing the latter is termed a prosthetic group; most such groups contain an atom of metal such as copper or iron. A cofactor that is bound loosely to the apoenzyme and can be readily separated from it is called a coenzyme.
Detailed explanation-3: -Apoenzyme-An enzyme that requires a cofactor but does not have one bound. An apoenzyme is an inactive enzyme, activation of the enzyme occurs upon binding of an organic or inorganic cofactor. Holoenzyme-An apoenzyme together with its cofactor. A holoenzyme is complete and catalytically active.
Detailed explanation-4: -Cofactor proteins bind both the proteinase (enzyme) and the proenzyme (substrate). They bind to lipid membranes, either to the surfaces or, in the case of integral proteins (tissue factor and thrombomodulin), spanning the cell membrane.