NURSING ANM AND GNM

Detailed explanation-1: -There are allosteric activators as well as inhibitors. Allosteric activators bind to locations on an enzyme away from the active site, inducing a conformational change that increases the affinity of the enzyme’s active site(s) for its substrate(s).

Detailed explanation-2: -Allosteric enzymes are activated or inhibited by substances produced in the pathway in which the enzymes function. These substances are called modulators and can alter the activity of allosteric enzymes by changing their conformation.

Detailed explanation-3: -An allosteric inhibitor binds to a distinct site on the surface of the enzyme or receptor that is independent of the substrate-binding domain. This allosteric binding mechanism can occur in one of two distinct ways: noncompetitive inhibition and uncompetitive inhibition.

Detailed explanation-4: -Prominent examples of allosteric enzymes in metabolic pathways are glycogen phosphorylase (41), phosphofructokinase (9, 80), glutamine synthetase (88), and aspartate transcarbamoylase (ATCase) (103).