NURSING ANM AND GNM

Detailed explanation-1: -Cholera diarrhoea is due to the action of a toxin that acts on all animal cells by stimulating the enzyme adenylate cyclase, which catalyses the production oc cyclic AMP from ATP.

Detailed explanation-2: -Incubation with 3 micrograms/ml cholera toxin (CT) at 37 degrees C induces an elevation of cellular cAMP beginning 10-15 min after initial exposure. The response is linear with time for 40-50 min and causes a six-to eightfold increase over control levels at steady state.

Detailed explanation-3: -The A subunit is responsible for activation of adenylate cyclase located on the basolateral cellular membrane.