NURSING ANM AND GNM

Detailed explanation-1: -In the final decades of the 19th century, Koch conclusively established that a particular germ could cause a specific disease. He did this by experimentation with anthrax. Using a microscope, Koch examined the blood of cows that had died of anthrax. He observed rod-shaped bacteria and suspected they caused anthrax.

Detailed explanation-2: -The “one pathogen to one disease” paradigm was developed based on the germ theory of disease that was formulated by Robert Koch the late 19th century and shaped the development of diagnostic microbiology in medicine.

Detailed explanation-3: -Robert Koch, Germany The cultured microorganism should cause disease when introduced into a healthy organism. The microorganism must be re-isolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent.

Detailed explanation-4: -In 1876 Koch built upon the work of Pasteur by proving that specific microbes caused specific diseases. He worked hard to find out which, this was called ‘microbe hunting’. He successfully identified the following different bacteria that caused anthrax (1876) septicaemia (1878), tuberculosis (1882) and cholera (1883).

Detailed explanation-5: -The germ theory of disease states that many diseases are caused by microorganisms such as bacteria, viruses, protozoa, or fungi. These diseases are caused by the growth and replication of microorganisms. The germ theory of disease was devised by Louis Pasteur.