NURSING ANM AND GNM

NURSING EXAM QUESTIONS

MICROBIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
In Kreb cycle Melate is formed by catalysis of ____ enzyme.
A
Succinate dehydrogenase
B
Oxaloacetate
C
Fumarate
D
Isocitrate dehydrogenase
Explanation: 

Detailed explanation-1: -Step 7: Fumarate gets converted to malate by the addition of one H2O. The enzyme catalysing this reaction is fumarase. Step 8: Malate is dehydrogenated to form oxaloacetate, which combines with another molecule of acetyl CoA and starts the new cycle.

Detailed explanation-2: -The enzyme fumarase catalyzes the reversible hydration of fumarate to malate.

Detailed explanation-3: -Fumarate Hydratase In the mitochondria, FH catalyses the hydration of fumarate to generate malate as part of the Krebs cycle. This pathway is not only essential for the production of cellular energy, but also forms a central metabolic hub to generate macromolecular precursors.

Detailed explanation-4: -Answer and Explanation: The enzyme responsible for the conversion of fumarate to malate is fumarase, or fumarate hydratase. The enzyme catalyzes the reversible process of fumarate to malate via hydration/dehydration reactions.

There is 1 question to complete.