NURSING ANM AND GNM

Detailed explanation-1: -According to the induced fit theory by Daniel Koshland, binding of substrate to the enzyme brings a conformational change in the enzyme to either enhance or inhibit its activity. The active site keeps changing its shape until it is bound to the substrate, the final binding gives a proper shape to the enzyme.

Detailed explanation-2: -These two extreme possibilities are known as induced fit and conformational selection respectively. The concept of induced fit was introduced by Daniel Koshland and was first used to describe the formation of the catalytically competent conformation of an enzyme active site upon ligand binding [1].