NURSING ANM AND GNM

Detailed explanation-1: -Insulin was the first protein drug to be produced commercially in bacteria. In 1978, a version of the human gene that encodes insulin was cloned and introduced into E. coli. The bacteria were shown to produce a form of human insulin.

Detailed explanation-2: -The first genetically engineered, synthetic “human” insulin was produced in 1978 using E. coli bacteria to produce the insulin. Eli Lilly went on in 1982 to sell the first commercially available biosynthetic human insulin under the brand name Humulin.

Detailed explanation-3: -Insulin is produced in a precursor form called proinsulin, which consists of a single chain of protein building blocks (amino acids). The proinsulin chain is cut (cleaved) to form individual pieces called the A and B chains, which are joined together by connections called disulfide bonds to form insulin.