NURSING ANM AND GNM

Detailed explanation-1: -The TCA cycle is an amphibolic pathway. Anaplerotic reactions replenish TCA cycle intermediates when they leak away from the cycle. Oxaloacetate leaks away from the TCA cycle to form pyrimidines and glucose. Succinyl-CoA leaks away from the TCA cycle to form the porphyrins (including heme).

Detailed explanation-2: -Because the citric acid cycle functions in both catabolism (Figure 11.1) and anabolism (Figure 11.2), we call it an amphibolic pathway. The citric acid cycle plays a pivotal role in cellular respiration, has multiple interconnections with other pathways, and provides for interconversions of numerous metabolites.