NURSING ANM AND GNM

Detailed explanation-1: -Exogenous pyrogens are substances, which originate outside the body and which are capable of inducing interleukins. Endogenous pyrogens are substances, which originate inside the body and which are capable of inducing fever by acting on the hypothalamic thermoregulatory centre.

Detailed explanation-2: -The endotoxins are extracted from and associated with the cell structure (cell wall). Good examples of pyrogen producing bacteria are S. typhosa, E. coli, and Ps.

Detailed explanation-3: -There are two types of natural pyrogens: (1) endogenous pyrogens that the host’s pyrogen cytokines and (2) exogenous pyrogens that are microbial substance (e.g. lipopolysaccharides in the cell wall of certain bacteria).