Activated T-cells release IFN-γ to induce an inflammatory activated macrophage stimulating ROS, proteases and cytokines. Whilst other cells that release IL-4 induce a repair activated macrophage to secrete growth factors and remodelling collagenases

PATHOLOGY AND GENETICS

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

Activated T-cells release IFN- to induce an inflammatory activated macrophage stimulating ROS, proteases and cytokines. Whilst other cells that release IL-4 induce a repair activated macrophage to secrete growth factors and remodelling collagenases

A	True
B	False
C	Either A or B
D	None of the above

Explanation:

Detailed explanation-1: -The pro-inflammatory cytokine interferon (IFN-) promotes the development of a T-helper (Th) 1 T cell response [1]. In addition, it synergizes with TNF to activate macrophages (M), promoting the induction of nitric oxide synthase (NOS2) which participates in killing of M. tuberculosis [2].

Detailed explanation-2: -IFN- primes macrophage activation by increasing phosphatase and tensin homolog via downregulation of miR-3473b. J Immunol.

Detailed explanation-3: -Upregulation of cell surface MHC class I by IFN- is crucial for host response to intracellular pathogens and tumor cells, due to cytotoxic T cell activation, promoting cell-mediated immunity.

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PATHOLOGY AND GENETICS