NURSING EXAM QUESTIONS
PATHOLOGY AND GENETICS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Polyclonal antibodies
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Monoclonal antibodies
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Neither
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Both
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Detailed explanation-1: -Polyclonal antibodies (PAbs) are a mixture of antibodies that are secreted by different B cell lineages. These antibodies are actually a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope on an antigen.
Detailed explanation-2: -Polyclonal antibodies: Advantages and disadvantages Higher overall antibody affinity against the antigen due to the recognition of multiple epitopes.
Detailed explanation-3: -Binding between the antibody and the epitope occurs at the Antigen Binding Site, which is called a paratope and is located at the tip of the variable region on the antibody.
Detailed explanation-4: -Polyclonal antibodies can be used for induction or for treatment of rejection, and include antithymocyte globulins (ATG) and antilymphocyte globulins (ALG). Antilymphocyte globulins were a component of the first successful immunosuppressive regimens in the 1960s.
Detailed explanation-5: -A polyclonal antibody is a mixture of antibodies recognizing multiple epitopes on a target protein.