NURSING ANM AND GNM

Detailed explanation-1: -A myeloblast is an immature precursor cell found in the bone marrow. This means that a myeloblast will change (mature or differentiate) into a healthy white blood cell called an agranulocyte or a monocyte. In AML, myeloblasts do not mature, and grow and multiply out-of-control.

Detailed explanation-2: -Acute myeloid leukaemia (AML) is caused by a DNA mutation in the stem cells in your bone marrow that produce red blood cells, platelets and infection-fighting white blood cells. The mutation causes the stem cells to produce many more white blood cells that are needed.

Detailed explanation-3: -In CML, too many blood stem cells become a type of white blood cell called granulocytes. These granulocytes are abnormal and do not become healthy white blood cells. They are also called leukemia cells.

Detailed explanation-4: -Approximately 80 percent of patients with chronic phase CML will be disease free for 5 years after transplant. In patients with accelerated phase CML, approximately 40 to 50 percent are disease free after 5 years, and only 10 to 20 percent of blast phase patients are alive and disease free after 5 years.