NURSING ANM AND GNM

Detailed explanation-1: -Paget’s disease of bone is a chronic disease of the skeleton. In healthy bone, a process called remodeling removes old pieces of bone and replaces them with new, fresh bone. Paget’s disease causes this process to shift out of balance, resulting in new bone that is abnormally shaped, weak, and brittle.

Detailed explanation-2: -Paget’s disease of bone disrupts the normal cycle of bone renewal, causing bones to become weakened and possibly deformed. It’s a fairly common condition in the UK, particularly in older people. It’s rare in people under 50 years of age.

Detailed explanation-3: -Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affect the bones. The term “osteogenesis imperfecta” means imperfect bone formation.

Detailed explanation-4: -The English surgeon Sir James Paget first described chronic inflammation of bone as osteitis deformans in 1877. Paget disease, as the condition came to be known, is the second most common bone disorder (after osteoporosis) in elderly persons.

Detailed explanation-5: -As the disease starts, the body loses much more bone than it makes. As Paget’s disease progresses, new bone forms at a faster rate than the rate at which old bone is removed. However, the new bone does not form correctly, leading to larger bones that are misshapen, weaker, and softer than normal bone.