NURSING ANM AND GNM

Detailed explanation-1: -Cross-linking of collagen refers to the ability of collagen fibrils to form strong chemical bonds with adjacent fibrils. In the cornea, collagen cross-linking occurs naturally with aging due to an oxidative deamination reaction that takes place within the end chains of the collagen.

Detailed explanation-2: -The general consensus is that as collagen ages there is an increase in the stiffness with loss of elasticity and that this is due to an increase in covalent intermolecular cross-linking between collagen molecules which develops with age (1).

Detailed explanation-3: -CXL is a technique of strengthening the corneal tissue by using riboflavin and ultraviolet-A light to halt the progression of progressive keratoconus. In CXL, riboflavin act as a photosensitizing agent, and UVA improves the formation of intra and interfibrillar covalent bonds by oxidative photosensitization.

Detailed explanation-4: -Collagen crosslinks, part of the matrix of bone upon which bone mineral is deposited, are biochemical markers the excretion of which provide a quantitative measurement of bone resorption. Elevated levels of urinary collagen crosslinks indicate elevated bone resorption.