NURSING ANM AND GNM

Detailed explanation-1: -Granulation tissue is an important component in the wound healing process. Wounds can heal by primary intention (wound edges approximate easily) and secondary intention (wounds edges do not approximate). Granulation tissue matrix will fill wounds that heal by second intention.

Detailed explanation-2: -Cells and proliferating capillaries are the two major components of granulation tissue. The cells are chiefly fibroblasts and inflammatory cells-macrophages, lymphocytes, plasma cells, and neutrophils depending on the stage and development of the granula-tion tissue and the presence of infection.

Detailed explanation-3: -Macrophages enter the wound, and participate in the phagocytic process. In addition, macrophages release growth factors and cytokines that help bring in the proliferative phase of healing. These factors include PDGF, TGF-, -FGF, TNF-, interleukin 1 (IL-1), and IL-6.

Detailed explanation-4: -Wound healing is divided into four overlapping states: 1) homeostasis, 2) inflammatory, 3) proliferative, and 4) remodeling.