NURSING ANM AND GNM

Detailed explanation-1: -This enzyme plays an important role in pathogenesis of celiac disease. It works by deamidating gliadin which results in greater proliferative response of gliadin-specific T-cells that lead to mucosal inflammation and further B-cell activation in patients with HLA-DQ2 or-DQ8.

Detailed explanation-2: -Gliadin appears to be the primary cause of celiac disease. Gliadin is a peptide contained within gluten-containing foods, and upon ingestion causes inflammation due to stimulation of helper T-cells.

Detailed explanation-3: -Celiac disease is characterized by small intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals following the dietary ingestion of “gluten.” The pathogenesis of disease involves interactions between environmental, genetic, and immunologic factors.

Detailed explanation-4: -Gliadin is one of the main proteins in gluten. The test is used to help find out whether you have celiac disease, an autoimmune disease. If you have celiac disease, your immune system responds abnormally to gluten, which is mainly found in wheat, barley, and rye products.

Detailed explanation-5: -Celiac disease (CeD) is an immune mediated enteropathy triggered by ingestion of gluten in genetically predisposed individuals carrying human leucocyte antigen (HLA) DQ2 or DQ8.