NURSING ANM AND GNM

Detailed explanation-1: -Maturation is the final phase and occurs once the wound has closed. This phase involves remodelling of collagen from type III to type I. Cellular activity reduces and the number of blood vessels in the wounded area regress and decrease.

Detailed explanation-2: -Scar tissue formation characterizes the final Remodeling Phase (also known as Maturation). It may occur over months or years, depending on the initial severity of the wound, its location, and treatment methods. During this phase, the new tissue gradually becomes stronger and more flexible.

Detailed explanation-3: -Collagen III is the first to be synthesized in the early stages of wound healing and is replaced by collagen I, the dominant skin collagen. The initial random deposition of collagen during the granulation tissue formation is further enhanced by lysyl oxidase enzyme-induced covalent cross-linking.

Detailed explanation-4: -Maturation refers to the slow process of remodeling the final scar. Although sufficient scar tissue forms within a few weeks, so that any sutures can be removed safely, the body continues to work hard laying cables of collagen and reconfiguring the scar.