NURSING ANM AND GNM

Detailed explanation-1: -Barrett’s metaplasia occurs as a result of prolonged tissue injury in the esophagus due to chronic gastroesophageal reflux disease (GERD). One of the risk factors of GERD and its complications has been the increase in obesity, especially central adiposity.

Detailed explanation-2: -Barrett’s esophagus is the condition in which metaplastic columnar mucosa that predisposes to cancer development replaces the stratified squamous mucosa that normally lines the distal esophagus.

Detailed explanation-3: -Most of the esophagus is lined by squamous mucosa. Goblet cells normally line the intestines, not the esophagus. When goblet cells are found in a place where they are not supposed to be, like the lining of the esophagus, it is called intestinal metaplasia.

Detailed explanation-4: -Barrett’s esophagus is defined as columnar metaplasia of the esophagus. There is worldwide controversy regarding the diagnostic criteria of BE, mainly with regard to the requirement to histologically identify goblet cells in biopsies.