NURSING ANM AND GNM

Detailed explanation-1: -Basal epithelial cells proliferate and migrate over the granulation tissue to close the wound surface. Remodelling – fibroblast and capillary density decreases, and initial scar tissue is removed and replaced by ECM that is more similar to normal skin.

Detailed explanation-2: -Fibroblasts lay down scar tissue and like sculptors, remodel their work with time. The initial strands of collagen are woven into bigger bundles and the type of collagen is made more resilient with time. Much of the activity of the fibroblasts is in response to the stresses across the developing scar.

Detailed explanation-3: -Fibroblasts are responsible and lay the foundation for new extracellular matrix (ECM) for collagen and granulation tissue.

Detailed explanation-4: -Fibroblastic (Repair) Phase: 4 days – up to 6 weeks During this phase collagen fibers are set down in the damaged area in the form of scar tissue. This type of tissue is less tensile and weaker making it susceptible to damage if overloaded.

Detailed explanation-5: -The fibrous tissue is laid down by fibroblasts, which migrate to the injured area, proliferate and secrete collagen under the influence of numerous growth factors and cytokines.