NURSING ANM AND GNM

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NURSING EXAM QUESTIONS

PATHOLOGY AND GENETICS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
This is also strongly recommended in young children older than 3 months of age, because NK cell levels in this population may be reduced or absent at birth.
A
NK cell marker
B
Anergy
C
Skin Testing
D
None of the above
Explanation: 

Detailed explanation-1: -Natural killer cell deficiency (NKD) is a primary immunodeficiency where the main defect lies in CD56+CD3− natural killer (NK) cells which mediate cytotoxicity against tumors. Most cases are observed in children and adolescents with recurrent viral infections and cancer.

Detailed explanation-2: -Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient’s clinical immunodeficiency.

Detailed explanation-3: -In our study, we have shown that the number of lymphocytes and CD56bright NK cells decreased with age while the number of CD56dim NK cells increased.

Detailed explanation-4: -Human Cell Surface Markers. In humans, NK cells are typically defined as CD3-CD56+ cells that are also CD7+CD127-NKp46+T-bet+Eomes+. Different subtypes of human NK cells have been identified that are either CD3-CD56dimCD16+ or CD3-CD56brightCD16-.

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