NURSING ANM AND GNM

Detailed explanation-1: -Heparin is the only anticoagulant used to prepare samples for blood-gas analysis. There are two ways in which heparin can interfere with results. The first is high heparin concentration in blood, and the second is heparin dilution of blood if liquid rather than dried (lyophilized) heparin is used.

Detailed explanation-2: -Heparin is a commonly used anticoagulant, especially in clinical biochemistry and chemical measurement tests. It is the recommended anticoagulant for chemical measurement in blood or plasma tests, because of its minimal chelating properties, minimal interference with water, and relatively low cation concentration.

Detailed explanation-3: -The test is used to monitor heparin therapy to ensure that a person is receiving sufficient heparin for anticoagulation without causing excess bleeding. Since the test involves a chemical reaction color change (colorimetric), it is also known as chromogenic anti-Xa assay or anti-Xa assay, chromogenic.

Detailed explanation-4: -Adding too much liquid heparin (sodium or calcium) to the blood sample can lead to positive bias by binding to positive ions and lead to negative bias by increasing the acidity level of the blood gases and the diluting blood sample [12, 15, 16].