NURSING ANM AND GNM

Detailed explanation-1: -According to the European Pharmacopoeia standard for effervescent tablets, the disintegration time should be less than 5 min (Rotthäuser, Kraus, & Schmidt, 1998). As shown in Figure 4c, all the formulations disintegrated within 220 s (3.5 min), meeting the requirement.

Detailed explanation-2: -Effervescent tablets (ETs) can quickly disintegrate because of the gas-generating reaction of an acidic agent (e.g., citric acid) and an alkaline agent (e.g., sodium bicarbonate) when coming into contact with water, therefore accelerating the release and improving the bioavailability of the included drugs.

Detailed explanation-3: -Effervescent tablets are designed to release carbon dioxide upon contact with water, promoting their disintegration. Within a couple of minutes the tablets completely dissolve and the drug becomes available in solution.