NURSING ANM AND GNM

NURSING EXAM QUESTIONS

PHARMACOLOGY

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

How does steroid prevent desensitization of b2-adrenoceptors?

A	Steroid transports the internalized b2-adrenoceptors back to plasma membrane
B	Steroid increases the gene transcription of b2-adrenoceptors
C	Steroid binds to b2-adrenoceptors, inhibiting the internalization of the receptors
D	I don’t like kitkat ____

Explanation:

Detailed explanation-1: -Steroids not only seem to reduce bronchial inflammation and hyperreactivity, and thereby the distribution of inhaled drugs, but also attend to reverse beta 2-receptor subsensitivity.

Detailed explanation-2: -Desensitization of beta-adrenergic receptors means loss of receptor activity due to overstimulation by beta-mimetic drugs. Desensitization has been demonstrated in experimental studies using cell cultures, isolated organs and in vivo models.

Detailed explanation-3: -Corticosteroids may regulate beta(2)-receptor function by increasing expression of the receptor, restoring G-protein/beta(2)-receptor coupling, and inhibiting beta(2)-receptor downregulation.

There is 1 question to complete.