NURSING EXAM QUESTIONS
PHARMACOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The results showed that Herb X had an ED50 value of 300 mg and an LD50 value of 6,000 mg. What was the therapeutic index (T.I.) of Herb X?
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10
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20
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0.05
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0.2
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Explanation:
Detailed explanation-1: -Therapeutic index is defined as follows: LD50, or median lethal dose, is the dose of drug that causes death in 50% of experimental animals, and ED50, or median effective dose, is the dose that produces a specified effect (“response”) in 50% of the population under study.
Detailed explanation-2: -Introduction-general considerations on the therapeutic index In animal studies, the TI can be calculated as the lethal dose of a drug for 50 % of the population (LD50) divided by the minimum effective dose for 50 % of the population (ED50), i.e. TI = LD50/ED50.
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