NURSING ANM AND GNM

NURSING EXAM QUESTIONS

PHARMACOLOGY

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

What is the mechanism of action of montelukast?

A	Non-selective phosphodiesterase inhibitor
B	Leukotriene receptor antagonists
C	Long acting muscarinic antagonist
D	Monoclonal antibodies

Explanation:

Detailed explanation-1: -The main indication for leukotriene receptor antagonists is in treating chronic asthma. Leukotrienes are synthesized from arachidonic acid by the action of 5-lipoxygenase in many inflammatory cells in the airways.

Detailed explanation-2: -The leukotriene receptor antagonists block the activity of cysteinyl leukotrienes at their receptors (CysLT1) on bronchial smooth muscle and elsewhere, while the leukotriene synthesis inhibitors block the synthesis of all leukotrienes by interrupting the 5-lipoxygenase pathway.

Detailed explanation-3: -The leukotriene d4 receptor antagonist, montelukast, inhibits mast cell degranulation in the dermis induced by water avoidance stress.

There is 1 question to complete.