NURSING ANM AND GNM

Detailed explanation-1: -Because leucine and BCAAs stimulate protein synthesis, they are likely to contribute to the prevention of muscle atrophy. It has been reported that the administration of a BCAA-rich feed to middle-aged mice activated mTORC1 and suppressed atrophy [37].

Detailed explanation-2: -In an engineered ligament model, it has been shown that the addition of 50 M proline with 50 M ascorbic acid, to a media rich in AAs such as leucine and glycine, increased ligament collagen content from 1.34 ± 0.2% to 8.34 ± 0.37% (20).

Detailed explanation-3: -The Pivotal Role of Leucine in Order to Counteract the Loss of Muscle Mass. Metabolic studies have shown that subjects ≥65 years of age require about 2% more protein per meal in order to maximize muscle protein synthesis, and leucine supplementation has been shown to be potentially useful for this purpose (3, 10).