NURSING ANM AND GNM

Detailed explanation-1: -– Two types of desensitization, homologous and heterologous, were described. In homologous desensitization, only agonist-activated receptors are desensitized while in heterologous desensitization, both agonist-activated and non-activated receptors sharing the same signaling pathways are inactivated.

Detailed explanation-2: -While the different mechanisms for desensitization are still being characterized, there are currently four known mechanisms: uncoupling of receptors from associated G proteins, endocytosis, degradation, and downregulation.

Detailed explanation-3: -Two types of receptor desensitization can be distinguished. Homologous desensitization is mediated by agonist‐induced activation of the same receptor, whereas heterologous desensitization is caused by activation of a different receptor.