NURSING EXAM QUESTIONS
TOXICOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Arsenic has an LD50 of 15mg/kg. How many mg of arsenic is toxic to an individual who weighs 100 kg?
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15 mg
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1, 500 mg
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6.7 mg
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0.15 mg
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Explanation:
Detailed explanation-1: -LD50 can be calculated using the formula LD50 = ED50/3 x Wm x 10-4. It is expressed in mg/kg bw/d or milligram of a substance per kilo of body weight administered per day.
Detailed explanation-2: -LD50 less than 500 mg/kg indicates high toxicity. LD50 500 to 1, 000 mg/kg indicates moderate toxicity. LD50 1, 000 to 2, 000 mg/kg indicates low toxicity.
Detailed explanation-3: -LD50 is the abbreviation used for the dose which kills 50% of the test population. LC50 is the abbreviation used for the exposure concentration of a toxic substance lethal to half of the test animals. LD50 is expressed in milligrams per kilogram of body weight of the test animal (which must be mentioned).
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