NURSING EXAM QUESTIONS
TOXICOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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LD50-expose it to many lab animals at different concentrations
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wait for reports of death and mayham
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Its chemical structure
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which country it is from
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Detailed explanation-1: -Toxicity can be measured by the effect the substance has on an organism, a tissue or a cell. We know that individuals will respond differently to the same dose of a substance because of a number of factors including their gender, age and body weight. Therefore a population-level measure of toxicity is often used.
Detailed explanation-2: -Acute Oral Toxicity Tests Some acute toxicity tests (such as the “classical” LD50 test) are designed to determine the mean lethal dose of the test substance. The median lethal dose (or LD50) is defined as the dose of a test substance that is lethal for 50% of the animals in a dose group.
Detailed explanation-3: -LD50 can be calculated using the formula LD50 = ED50/3 x Wm x 10-4. It is expressed in mg/kg bw/d or milligram of a substance per kilo of body weight administered per day.