NURSING ANM AND GNM

Detailed explanation-1: -So, the example “LD50 (oral, rat) 5 mg/kg” means that 5 milligrams of that chemical for every 1 kilogram body weight of the rat, when administered in one dose by mouth, causes the death of 50% of the test group.

Detailed explanation-2: -The LC50 is the concentration of pesticide which is lethal to 50% of a population of test animals and is usually determined for a specific exposure period (e.g. inhalation for 4 hours).

Detailed explanation-3: -The concentration of a material in air which, on the basis of laboratory tests, is expected to kill 50% of a group of test animals when administered as a single exposure (usually 1 or 4 hours).

Detailed explanation-4: -LC50 is defined as the concentration in air at which 50 percent of the test animals (rats or mice) died, usually within 1 hour. A substance is considered extremely toxic if it has an LD50 of less than 5 mgs/kg of animal body weight. To humans, this is the equivalent of a taste (less than 7 drops).