NURSING EXAM QUESTIONS
TOXICOLOGY
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
LD50
|
|
|
LC50
|
|
|
LR50
|
|
|
LM50
|
Detailed explanation-1: -So, the example “LD50 (oral, rat) 5 mg/kg” means that 5 milligrams of that chemical for every 1 kilogram body weight of the rat, when administered in one dose by mouth, causes the death of 50% of the test group.
Detailed explanation-2: -LD50 – What is it? The term LD50 refers to an estimate of the amount of poison that, under control conditions, will be a lethal dose to 50% of a large number of test animals of a particular species. The value is expressed in milligrams of the substance being tested per kilogram of animal body weight (mg/kg).
Detailed explanation-3: -LD50 can be calculated using the formula LD50 = ED50/3 x Wm x 10-4. It is expressed in mg/kg bw/d or milligram of a substance per kilo of body weight administered per day.
Detailed explanation-4: -Oral LD50 (rat): 56 mg/kg. Oral (mouse): 61 mg/kg.