NURSING ANM AND GNM

Detailed explanation-1: -The causes and significance of drug interactions are multifaceted and include drug dose, serum drug level, route of administration, drug metabolism, duration of therapy, and patient factors, such as age, gender, weight and genetic predisposition (Heuberger, 2012).

Detailed explanation-2: -Abstract. Duration of drug action depends on several factors: the absolute amount of drug given; the pharmaceutical preparation; the reversibility of drug action; the half-life of the drug; the slope of the concentration-response curve; the activity of metabolites, and the influence of disease on drug elimination.