NURSING ANM AND GNM

Detailed explanation-1: -Ricin works by getting inside the cells of a person’s body and preventing the cells from making the proteins they need. Without the proteins, cells die. Eventually this is harmful to the whole body, and death may occur. Effects of ricin poisoning depend on whether ricin was inhaled, ingested, or injected.

Detailed explanation-2: -The plant toxin ricin is highly toxic for mammalian cells and is of concern for bioterrorism. Ricin belongs to a family of functionally related toxins, collectively referred to as ribosome inactivating proteins (RIPs), which disable ribosomes and halt protein synthesis.

Detailed explanation-3: -Ricin A chain (RTA) inhibits protein synthesis by removing a specific adenine from the highly conserved -sarcin/ricin loop in the large rRNA. Expression of RTA with its own signal sequence in yeast resulted in its translocation into the endoplasmic reticulum (ER) and subsequent glycosylation.

Detailed explanation-4: -Structure. Ricin is a heterodimer that consists of a 32 kilodalton A chain glycoprotein (light blue) linked by a disulfide bond to a 32 kilodalton B chain glycoprotein (green). The A chain is an alpha/beta protein which contains eight alpha helices (pink) and eight beta sheets (yellow). It has three domains.