NURSING EXAM QUESTIONS
TOXICOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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An organ that stores the xenobiotic or its metabolite.
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An organ that is damaged by the xenobiotic or its metabolite.
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An organ that absorbs the xenobiotic
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An organ that metabolizes the xenobiotic
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Detailed explanation-1: -The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in the metabolism of xenobiotics render this organ particularly susceptible to injury by chemicals to which we are ubiquitously exposed.
Detailed explanation-2: -Skin is a protective layer against various xenobiotic substances. Chemically reactive toxic agents can cause direct damage to this layer, when they come in contact with it. Various keratolytic agents and blister forming chemicals may cause direct skin injury.
Detailed explanation-3: -Hepatic enzymes are responsible for the metabolism of xenobiotics by first activating them (oxidation, reduction, hydrolysis and/or hydration of the xenobiotic) and then conjugating the active secondary metabolite with glucuronic or sulphuric acid or glutathione, followed by excretion in bile or urine.