NURSING EXAM QUESTIONS
TOXICOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Hair Analysis
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Urine Analysis
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Blood Analysis
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None of the above
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Detailed explanation-1: -Common instruments used in drug analysis of hair samples is liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS). These instruments are used because of the ability to positively detect trace concentrations of drugs.
Detailed explanation-2: -HPLC is the most commonly used technique for the quantification of drugs in formulations. The principal advantages of HPLC compared to column chromatography are improved resolution of the separated substances, faster separation time and the increased accuracy, precision and sensitivity.
Detailed explanation-3: -As noted in Table 1, since drugs are generally excreted quickly via the urine, but trapped indefinitely in the hair, the time limitations restricting urinalysis are improved by using hair specimens. This is the most prominent advantage of hair specimens.