PATHOLOGY

Detailed explanation-1: -A checkpoint in the cell cycle is a critical control point where stoop and go-ahead signals can regulate the cycle. Animal cells generally have built-in stop signals that half the cell cycle at checkpoints until overridden by go-ahead signals.

Detailed explanation-2: -Each step of the cell cycle is monitored by internal controls called checkpoints. There are three major checkpoints in the cell cycle: one near the end of G1, a second at the G2/M transition, and the third during metaphase.

Detailed explanation-3: -A checkpoint is a stage in the eukaryotic cell cycle at which the cell examines internal and external cues and “decides” whether or not to move forward with division.

Detailed explanation-4: -Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis.