PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Free radicals
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Acidosis
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Alkalosis
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None of the above
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Detailed explanation-1: -An antioxidant is a molecule stable enough to donate an electron to a rampaging free radical and neutralize it, thus reducing its capacity to damage.
Detailed explanation-2: -Free radicals can be produced from non-enzymatic reactions of oxygen with organic compounds as well as those initiated by ionizing radiations. The nonenzymatic process can also occur during oxidative phosphorylation (i.e. aerobic respiration) in the mitochondria (4, 5, 8).
Detailed explanation-3: -Oxidation of protein: Free radical causes CI by oxidation of protein macromolecules of cell causing cross linkage in the amino acid sequences of protein and fragmentation of polypeptides. 3. Effect on DNA damage: Free radical breaks DNA fragments to single strand, so there will be formation of DNA which is defective.
Detailed explanation-4: -Singlet oxygen (when oxygen is “split” into single atoms with unpaired electrons) Hydrogen peroxide. Superoxides. Hydroxyl anions. 23-Oct-2022