PATHOLOGY

Detailed explanation-1: -In their model, -cells are located in the islet core and -cells are arranged at the periphery and along intraislet capillaries. These views were challenged by more recent publications claiming that endocrine cell types were dispersed throughout the human islets (8, 12).

Detailed explanation-2: -The islets of Langerhans contain four cell types that each secrete a different peptide: alpha cells secrete glucagon, beta cells secrete insulin, delta cells secrete somatostatin, and P (F) cells secrete pancreatic polypeptide.

Detailed explanation-3: -The normal human pancreas contains about 1 million islets. The islets consist of four distinct cell types, of which three (alpha, beta, and delta cells) produce important hormones; the fourth component (C cells) has no known function.