PATHOLOGY

Detailed explanation-1: -Tumor suppressor genes help protect your body from cancer. They do that by managing cell growth. When these genes mutate, or change, your cells may multiply uncontrollably and become tumors. Medical researchers are evaluating whether targeted therapy for cancer can reactivate mutated tumor suppressor genes.

Detailed explanation-2: -Tumor suppressor genes represent the opposite side of cell growth control, normally acting to inhibit cell proliferation and tumor development. In many tumors, these genes are lost or inactivated, thereby removing negative regulators of cell proliferation and contributing to the abnormal proliferation of tumor cells.

Detailed explanation-3: -Oncogenes end up promoting uncontrolled cell growth and division, causing normal cells to become cancerous. On the other hand, tumor suppressor genes are genes that code for protein products that regulate and slow down the cell cycle, and also promote apoptosis, which is programmed cell death.