PATHOLOGY

Detailed explanation-1: -Apoptosis is the process of programmed cell death. It is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also plays a role in preventing cancer.

Detailed explanation-2: -Apoptosis is an active process characterized by cell shrinkage, nuclear and cytoplasmic condensation, chromatin fragmentation, and phagocytosis of the apoptotic cell.

Detailed explanation-3: -Apoptosis is characterised by a series of typical morphological features, such as shrinkage of the cell, fragmentation into membrane-bound apoptotic bodies and rapid phagocytosis by neighbouring cells.

Detailed explanation-4: -There are 4 stages of apoptosis: the initiation or stimulus for cell death, the active programmed cell death when the events become irreversible, phagocytosis of the dead cellular material, and inhibitory mechanisms of apoptosis.

Detailed explanation-5: -Cell shrinks. Cell fragments. Cytoskeleton collapses. Nuclear envelope disassembles. Cells release apoptotic bodies. 28-Apr-2013