PATHOLOGY

Detailed explanation-1: -Cancer is a disease of the cell cycle. Cancer cells do not respond to the signals and safeguards that are in place. Because cancer cells don’t respond appropriately, they grow uncontrollably and can eventually damage the tissues around them.

Detailed explanation-2: -Overall, the cell cycle has many regulatory steps that are crucial to maintaining homeostasis inside of the cells during the replication of DNA and the division of cells. Mutation inside specific genes can lead to the loss of balance inside the cells, thus resulting in cancer growth.

Detailed explanation-3: -Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. When the cell cycle proceeds without control, cells can divide without order and accumulate genetic errors that can lead to a cancerous tumor .

Detailed explanation-4: -If a checkpoint fails or if a cell suffers physical damage to chromosomes during cell division, or if it suffers a debilitating somatic mutation in a prior S phase, it may selfdestruct in response to a consequent biochemical anomaly.