PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Caspases need to be cleaved to initiate apoptosis
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True
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False
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Sometimes
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None of the above
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Explanation:
Detailed explanation-1: -Apoptosis occurs randomly during embryonic development of a nematode. Apoptosis is triggered only by signals from outside the cell. All of the listed responses are correct.
Detailed explanation-2: -Once activated, caspase-3 will cleave key structural proteins, cell cycle proteins, and DNase proteins, such as poly(ADP-ribose) polymerase, gelsolin, ICAD/DFF, and DNA-dependent kinase11, 12, 13. These cleavage events result in the blebbing and condensing of cells that ultimately leads to cell death14.
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