PATHOLOGY

Detailed explanation-1: -Cell cycle checkpoints are critical to prevent the cell from progressing to the next phase of the cell cycle before the prior phase has been completed. Premature entry into the next phase of the cell cycle can result in catastrophic consequences for the cell and cell death.

Detailed explanation-2: -Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis.

Detailed explanation-3: -There are three major checkpoints in the cell cycle: one near the end of G1, a second at the G2/M transition, and the third during metaphase. Positive regulator molecules allow the cell cycle to advance to the next stage.

Detailed explanation-4: -In the cell cycle, there are three major checkpoints-the G1 checkpoint, the G2 checkpoint, and the spindle checkpoint.

Detailed explanation-5: -What is the purpose of a checkpoint? To verify whether the processes at each phase of the cell cycle have been accurately completed before progression into the next phase.