PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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DNA integrity (Is any part of the DNA damaged?)
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DNA replication (Is the DNA replication completed in the S phase?)
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Cell’s size (Does the cell large increase its size or large enough for cell division?)
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Nutrients (Does the cell have enough reserve energy and nutrients for cell division?)
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Detailed explanation-1: -At the G2 checkpoint, the cell checks for: DNA damage. DNA replication completeness.
Detailed explanation-2: -The G2 checkpoint ensures all of the chromosomes have been replicated and that the replicated DNA is not damaged before cell enters mitosis. The M checkpoint determines whether all the sister chromatids are correctly attached to the spindle microtubules before the cell enters the irreversible anaphase stage.
Detailed explanation-3: -G2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they follow normal transition to the M phase.
Detailed explanation-4: -G2 checkpoint – DNA quality control After the second growth phase, the cell checks that the DNA was completely and correctly replicated during the S phase.