PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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True
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False
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Either A or B
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None of the above
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Detailed explanation-1: -The levels of the different cyclins vary considerably across the cell cycle, as shown in the diagram at right. A typical cyclin is present at low levels for most of the cycle, but increases strongly at the stage where it’s needed.
Detailed explanation-2: -M-phase cyclins form M-CDK complexes and drive the cell’s entry into mitosis; G1 cyclins form G1-CDK complexes and guide the cell’s progress through the G1 phase; and so on. All CDKs exist in similar amounts throughout the entire cell cycle.
Detailed explanation-3: -Answer-cyclin is made continuously during cell cycle. A CDK bound to a G1/S cyclin can catalyze the phosphorylation of retinoblastoma protein . …
Detailed explanation-4: -The expression level of cyclins is primarily regulated by transcription of cyclin genes and turnover of cyclin proteins [4, 5]. Over the past two decades, however, translation has also emerged as a key point at which the levels of cell cycle regulators are modulated.