PATHOLOGY

Detailed explanation-1: -During anaphase identical sister chromatids separate and move towards opposite poles of the mitotic spindle . In the spindle, kinetochore microtubules have their plus ends embedded in the kinetochore and their minus ends at the spindle pole.

Detailed explanation-2: -A central feature of mitosis is segregation of sister chromatids to opposite poles during anaphase.

Detailed explanation-3: -During mitosis, several types of microtubules are active. The motor proteins associated with the interpolar microtubules drive the assembly of the spindle. Note the other types of microtubules involved in anchoring the spindle pole and pulling apart the sister chromatids.

Detailed explanation-4: -During anaphase A, the chromosomes move to the poles and kinetochore fiber microtubules shorten; during anaphase B, the spindle poles move apart as interpolar microtubules elongate and slide past one another. Many cells undergo both anaphase A and B motions, but in some cases one or the other motion dominates.

Detailed explanation-5: -During anaphase, sister chromatids separate and move to the spindle poles (Figures 2 and 3). Anaphase consists of two phases, anaphase A and B.