PATHOLOGY

Previous
Next

PATHOLOGY MCQ

CELL DAMAGE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Early-onset Alzheimer’s disease affects people under the age of 65. Less than five percent of people who are diagnosed with Alzheimer’s disease have this type. Many cases of early-onset Alzheimer’s disease are inherited, a type known as familial Alzheimer’s disease (FAD). Which statement is best supported by this information?
A
FAD is the result of a genetic change in one or more chromosomes.
B
Natural selection will continue to reduce the incidence of FAD.
C
FAD affects only the genes of middle-aged people.
D
Deletion of one amino acid causes FAD.
Explanation: 

Detailed explanation-1: -About 5% to 6% of people with Alzheimer’s disease develop symptoms before age 65. So if 6 million Americans have Alzheimer’s, around 300, 000 to 360, 000 people have the young-onset form of the disease.

Detailed explanation-2: -Early-onset Alzheimer disease, which makes up about 5% to 6% of all cases of Alzheimer disease, is distinct from late-onset Alzheimer disease in a number of clinical, genetic, neurobiological, and management features. Early-onset Alzheimer disease is the most common cause of early-onset neurodegenerative dementia.

Detailed explanation-3: -Genetic (familial) Alzheimer disease. A few hundred people have genes that directly contribute to Alzheimer disease. These people start showing symptoms of the disease in their 30s, 40s, or 50s.

Detailed explanation-4: -Some cases of early-onset Alzheimer disease are caused by gene mutations that can be passed from parent to child. This results in what is known as early-onset familial Alzheimer disease (FAD). Researchers have found that this form of the disorder can result from mutations in the APP, PSEN1, or PSEN2 genes.

There is 1 question to complete.
Previous
Next