PATHOLOGY

Detailed explanation-1: -In fat necrosis, the glycoprotein enzyme lipase frees fatty acids from triglycerides. The released fatty acids then will be combined with calcium and would form soaps which become visible as white pale deposits [8].

Detailed explanation-2: -Calcification is occasionally associated with nodular cystic fat necrosis. The mechanisms of dystrophic calcification are thought to be due to the susceptibility of subcutaneous fat to trauma or ischemia. Once the fat cell is damaged, the liberated lipid then undergoes hydrolysis into glycerol and fatty acids.

Detailed explanation-3: -Gross and microscopic appearances of the fat necrosis depend on the age of the lesion. Macroscopically, early lesions appear as hemorrhagic foci or areas of indurated fat. In time, the lesion may become bright yellow (saponification), chalky white (calcification), or yellow-gray (fibrosis).

Detailed explanation-4: -Symptoms of fat necrosis Fat necrosis feels like a firm, round lump or lumps. It’s usually painless, but in some people it may feel tender or even painful. The skin around the lump may look thickened, red, bruised or occasionally dimpled. Sometimes fat necrosis can cause the nipple to be pulled in.