PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Mutations split
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Mutations passed to future generations
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Mutations return normal
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Mutations are not passed to future generations
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Detailed explanation-1: -DNA damage not only arrests the cell cycle in G2, but also slows the progression of cells through S phase and arrests cell cycle progression at a checkpoint in G1. This G1 arrest may allow repair of the damage to take place before the cell enters S phase, where the damaged DNA would be replicated.
Detailed explanation-2: -Failure in DNA repair will cause cell death, even in yeast, which lacks the apoptosis program. Death from excessive DNA damage is passive, and should be experimentally distinguished from apoptosis, which is an active process.
Detailed explanation-3: -DNA damage can affect normal cell replicative function and impact rates of apoptosis (programmed cell death, often referred to as ‘cellular senescence’). Alternatively, damage to genetic material can result in impaired cellular function, cell loss, or the transformation of healthy cells to cancers.